SPECTROPHOTOMETIC ANALYSIS OF GATIFLOXACIN TABLETS USING MIXED HYDROTROPHY
AbstractA new, simple, safe, accurate and reproducible spectrophotometric analytical method was developed for the quantitative estimation of gatifloxacin in solid dosage form by mixed hydrotropic agents. The enhancement of solubility of drug gatifloxacin was more than 15 fold in mixed hydrotropic solution (20% N,N dimethyl urea and 20% sodium citrate solution) as compared to solubility in distilled water. Therefore, it was thought worthwhile to solubilize this poorly water soluble drug from fine powder of its tablets by this novel mixed hydrotropic solubilization technique and then carryout its spectrophotometric estimation at 333 nm (20% N,N dimethyl urea and 20% sodium citrate being non-interfering in the estimation). The results of the analysis were validated statistically and by recovery studies & its follows Beer’s law in concentration range of 10-60 mcg/ml. The percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error. Thus, the method was accurate providing additional advantage of being cost effective and environment friendly.
Article Information
36
2709-2711
382
1162
English
Ijpsr
Rounak Shrivastava*, Rahul Jain and Shailesh Patel
Department of Pharmacy, COP, IPS Academy, Rajendra Nagar, Indore, Madhya Pradesh, India
20 June, 2011
27 July, 2011
21 September, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(10).2709-11
01 October, 2011
Download