SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TRAZODONE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
AbstractSpectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These method based on the formation of chloroform soluble ion-association complexes of TRH with bromphenol blue (BPB) and with chlorophenol red (CPR) in buffer of pH 2.0 (for BPB) and buffer of pH of 4 (for CPR) with absorption maximum at 420 nm and at 410 nm for BPB and CPR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increase in concentration of TRH, which was corroborated by the calculated correlation coefficient values (0.9996, 0.9945). The systems obeyed Beer’s law in the range of 0.2-14.5 and 0.2-14.1m g/ml for (BPB) and (CPR), respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, accurate and suitable for quality control applications.
Article Information
6
2798-2800
409
1349
English
Ijpsr
Yasser A. Z. *, Rabie S. Farag , M. Elnawawy Ahmed M. A. , Sayde R. Abd Alsalam
Medico-Legal Department Ministry of Justice, Cairo, Egypt
10 June, 2011
23 September, 2011
27 October, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(11).2798-00
01 November, 2011
Download