SPREADING OUT OF ACECLOFENAC SUSTAINED RELEASE MICROCAPSULES BASED ON HPMC 50 CPS BY EMULSION SOLVENT EVAPORATION TECHNIQUE

Sustained released Aceclofenac microcapsules based on synthetic hydrophilic polymer hydroxypropyl methylcellulose (HPMC) were developed in this study in an attempt to design a dosage form that would manifest desirable release profile. W/O emulsion solvent evaporation technique was employed. Various release retarding agents were used to provide the analgesic and anti-inflammatory action of aceclofenac for prolong period of time. Microcapsules were prepared at a fixed stirring rate of 1000 rpm. Polymeric solution containing aceclofenac was emulsified by light liquid paraffin (LLP) which was initially emulsified by 1% (w/w of the continuum) lipophilic surfactant Span 80. The formulated microcapsules were evaluated for drug-polymer drug loading efficiency, micromeritic properties, surface morphology study, in-vitro drug release kinetics. It was found that all formulations showed satisfactory flow behavior. The maximum loading efficiency of was found to be 87.42%. SEM study showed that the microcapsules were discrete and spherical shaped. Efficacy of the dosage forms were evaluated in terms of in-vitro dissolution studies which showed statistically significant difference among the drug release profile from different polymeric blend as well as their increasing concentration. However, by increasing the polymer concentration, the rate of drug release from the microcapsules decreases dramatically. Drug release from all formulations followed Korsemeyer-Peppas kinetics and release mechanisms followed non-Fickian or anomalous type release