SQUALENE: A POTENTIAL ANTI-ALZHEIMER’S COMPOUND IN ALBINO RAT

Alzheimer’s disease, the most scattered neurodegenerative disease causes progressive destruction in serviceable performances and continuous reduction in cognitive activities and memory in aged people. It is estimated that people suffering from AD is about 10% between 65-70 years and 50% in people above 85years of age and this number will double every two decades. Even though extensive research has been carried out for decades, there is no specific therapeutic drug available for the permanent cure of Alzheimer`s Disease. In this study, squalene, a natural compound synthesized from marine shark liver oil is selected to evaluate its Anti-Alzheimer’s properties in Experimentally AD-induced Male Albino Rats. In the present study, in-vivo experiments were carried out to test the Anti-Alzheimer’s property of Squalene on Male Albino Rats under D-galactose-induced AD. The estimation of ACh and AChE content in the Cerebral Cortex and Hippocampus was done in different groups of rats at different time intervals. The results revealed that in experimentally AD-induced Rats, Squalene caused significant ACh content elevation while reducing AChE activity levels in both selected regions viz. Cerebral Cortex and Hippocampus, which is the key requirement for treating AD. From the results obtained in the present investigation, it was finally inferred that squalene has a neuroprotective role against D-Galactose-induced Alzheimer’s disease. Since it resulted in the elevation of the cholinergic neurotransmitter in Hippocampus and Cerebral Cortex regions of the rat brain on both selected days of experimentation.