STANDARDIZATION, FORMULATION DEVELOPMENT AND CHARACTERIZATION OF ANTIULCER DRUG: MUKTA BHASMA
AbstractAyurveda is the holistic approach towards life, health, disease management through medicinal herbs minerals, diet and lifestyle leads to the great need for standardization of herbal medicine to maintain its safety and efficacy. Mukta bhasma is used in the treatment of bone metabolic disorders associated with calcium deficiency. It was prepared by Shodhana, Marana and Sharava samputa and the Standardization of bhasma are very necessary to confirm its identity and to determine its quality and purity. An attempt has been made to summarize the ancient and the advanced methods available for the standardization of bhasma. The dosage uniformity and patient compliance can be increased and adulteration can be decreased in ayurvedic powders by formulating them into tablets. The aim of the present work is to develop and evaluate Mukta Bhasma tablets using starch and acacia as a binder. The granules were prepared by the wet granulation method. The prepared tablets were evaluated for different parameters, acute toxicity of Mukta bhasma was conducted on albino rats. Mukta bhasma was administered orally in albino rats of single maximum limit dose 2000 mg/kg and general behavioral observation along with any mortality was recorded. Acute toxicity study shows that there is no adverse effect of bhasma on albino rats even at a single dose of 2000 mg/kg body weight that reveals that Mukta bhasma is safe in albino rats. The results suggest that this ayurvedic preparation cannot show any signs and symptoms of toxicity.
Article Information
19
183-191
906
1196
English
IJPSR
M. C. Utikar *, R. S. Pentewar, S. S. Thonte, P. H. Bhosale and M. T. Narhare
Department of Pharmaceutics, Channabasweshwar Pharmacy College, Latur, Maharashtra, India.
mokshutikar0006@gmail.com
29 March 2019
17 November 2019
24 December 2019
10.13040/IJPSR.0975-8232.11(1).183-91
01 January 2020