STRUCTURAL AND FUNCTIONAL ABNORMALITIES ASSOCIATED WITH HIGH FRUCTOSE DIET-INDUCED METABOLIC SYNDROME IN WISTAR ALBINO RATS
AbstractPurpose of the study: To assess Structural and functional abnormalities associated with High fructose diet-induced Metabolic syndrome in wistar albino rats. Materials and Methods: Metabolic syndrome is induced in adult male Wistar albino rats by feeding a combination of High Fructose Diet (55%) and Fructose enriched water (15%) for 75 days and kept as group 2 or HFrD Group. Normal male Wistar albino rats were kept as Normal control. During the entire course of study, weekly weight gain was monitored once a week in both groups. Biochemical investigations such as lipid profile, liver function test, and renal function test was carried out using standard methods. Routine histological studies were done to analyze the microstructural changes. The obtained data were statistically analyzed by students‘t’ tests and the values were considered statistically significant at p<0.05. Results: Chronic administration of a High fructose diet (HFrD) resulted in obesity, abnormal hepatic and renal functions in wistar rats. The gross and microstructural changes were minimal in the pancreas and heart, whereas significant damages were observed in the liver and kidneys. Conclusion: Consumption of a High fructose diet (HFrD) produces structural and functional damages in the liver and kidneys of wistar rats.
Article Information
30
4864-4869
1252 KB
400
English
IJPSR
V. Sreekala, R. Rajesh and Kamal Nayan Dwivedi
Department of Anatomy, World College of Medical Sciences and Research, Jhajjar, Haryana, India.
rajesh2361@gmail.com
18 August 2020
08 August 2021
12 August 2021
10.13040/IJPSR.0975-8232.12(9).4864-69
01 September 2021