STRUCTURAL ELUCIDATION OF CHITOSAN BASED HETEROCYCLIC COMPOUNDS OF ANTI-MICROBIAL AND ANTI-CANCER ACTIVITYAbstract
Schiff bases from chitosan and 5-nitro salicylaldehyde-aniline complexes represented the important structural subject in excess of biologically active molecules, including synthetic. The introduction of 5-nitro salicylaldehyde at C-2 nitrogen position and aniline at C-6 oxygen position of chitosan. The structure-activity relationship (SAR) of the double Schiff based chitosan, synthesized from the condensation reaction of equimolar amounts of 5-nitrosalicyl-aldehyde, chitosan, and aniline in DMSO. The chitin and the phenyl rings deviate from co-planarity with an inter and intra-molecular bond (–C2-N=CH–), (–C6–C=N–). The title compound C69H118N11O43 is not a planner, with a dihedral angle among the planes of the three aryl rings. The structure is a heterocyclic derivative constituting a stimulating class of compounds with synthetic flexibility and productive biological activities. The synthesized compound structurally categorized by FT-IR, 1H-NMR, GC-Mass spectra, and TG/DTA studies. The 1H-NMR spectroscopy used to determine the degree of acetylation in chitosan. The synthesized compound primarily parted for their in-vitro growth constraining activity against a different strain of bacterial and fungal. The in-vitro antioxidant activity of the mixture was determined by metal chelating activity and ferric falling antioxidant power assay. The in-vitro cytotoxicity tests of the ligand carried out tumour cell lines in only live cells. The derivatives have remarkable pharmaceutical activities as an anti-fungal, anti-cancer anti-bacterial, and anti-oxidant compound.
R. I. Malarselvi *, A. Deepika, C. R. Raja and R. Priscilla
Department of Physics, D. G. Government Arts College, Mayiladuthurai, Tamil Nadu, India.
05 July 2019
23 November 2019
17 April 2020
01 June 2020