STUDIES ON FORMULATION AND EVALUATION OF BILAYERED TABLETS OF CURCUMIN

Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of the successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The bi-layered tablet is a very different aspect of anti-inflammatory and analgesic. The purpose of this study was to develop and evaluate bilayered tablets of curcumin for the effective treatment of inflammation. The Immediate-release layer was prepared by using superdisintegrants- SSG and binder used xantham gum and the sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Before the preparation of the tablets, all the pre-formulation parameters were checked and the tablet of curcumin were prepared by direct compression method and was evaluated for physical characteristics like hardness, weight variation, drug content and friability. In-vitro release of drug was performed USP type I dissolution test apparatus using 0.1N HCl and phosphate buffer pH 7.4 as dissolution media and dissolution was continued for 12 h for the sustained release layer. It was found that all the formulations were within limit of the standard. The drug release of the tablet was in the range of 82.44% – 88.20% in 12 h. The rate of drug release follows the Higuchi model and First-order kinetics. It was concluded that the F4 formulation showed the optimum result as a bilayered tablet for the effective treatment of inflammation.