STUDY OF ELECTRODE KINETICS AND THERMODYNAMIC PARAMETERS OF TINIDAZOLE POLAROGRAPHYCALLYAbstract
The electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at different temperatures. The reduction of tinidazole was found to be irreversible so kinetic parameters (Ko fh, αn) are evaluated using Meites-Israel and Gaur-Bhargava’s methods. Thermodynamic parameters such as ∆Hp≠, ∆Hv≠, ∆G≠ and ∆S≠ are also evaluated.
Ashish Garg*, Yogesh Kumar, Om Prakash Meena, Mahipat Singh and R. Pandey
Lab. No. 303, Department of Chemistry, University of Rajasthan, JLN Marg, Jaipur, Rajasthan, India
17 December, 2010
21 February, 2011
04 March, 2011
01 April, 2011