SUSTAINED RELEASE OPHTHALMIC IN-SITU GELS OF DORZOLAMIDE HCl FOR GLAUCOMA-AN APPROACH TO FORMULATION AND IN-VITRO EVALUATIONAbstract
The objective of the present investigation was to formulate the thermosensitive ophthalmic in-situ gels of Dorzolamide HCl for the treatment of glaucoma. Dorzolamide HCl is presently available as conventional eye drops, which has demerits like pre-corneal elimination, lachrymal drainage and no sustained effect leading to poor bioavailability and hence there was a need to develop a better, stable and sustained drug release dosage form. Dorzolamide HCl loaded thermosensitive ophthalmic in-situ gels were prepared by cold method using poloxamers as thermo-sensitive polymers in different concentrations with HPMC K4M as viscosifier which was used in three different concentrations. A total of six formulations were made and evaluated for para-meters, namely appearance, clarity, pH, gelling capacity, gelation temperature, rheological study, drug content, and in-vitro drug release studies. All the evaluation parameters were within limits. Among all six formulations, one (DF-5) showed the highest drug release, and this formulation was evaluated for sterility, isotonicity, and in-vitro ocular irritation study, where all these parameters were found to be satisfactory. The results of the current study conclude that Dorzolamide HCl in-situ gel is a better alternative approach providing sustained drug release for the management of glaucoma.
D. S. Sandeep *, R. N. Charyulu and A. Dubey
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte, Mangaluru, Karnataka, India.
21 December 2019
23 January 2020
14 March 2020
01 December 2020