SYNTHESIS AND ANTIBACTERIAL SCREENING OF FIVE NEW AZOMETHINE DERIVATIVES OF 2-AMINO-2-METHYL-1-PROPANOL

In this present investigation author reporting the anti-bacterial activity of five new azo methines, namely 2-((1-hydroxy-2- methyl propan-2-ylimino) methyl)-6-methoxyphenol (AZM₁), 4-((1-hydroxy-2- methyl propan-2-ylimino) methyl)-6-methoxyphenol(AZM₂), 4-((1-hydroxy-2-methyl propan-2-ylimino) methyl)-2,6,dimethxy phenol (AZM₃), 2- (3, 4- dimethoxybenzylideneamino)- 2- methylpropan-1-ol (AZM₄) and 2-(3,4,5-trimethoxybenzylideneamino)-2-methylpropan-1-ol (AZM₅) against and Bacillus thuringiensis, E. coli bacteria. All new five novel Azomethines were synthesized by the condensation of 2-Amino-2-Methyl-1-Propanol with 2- Hydroxy- 3- methoxybenzaladehyde, 4-Hydroxy- 3- Methoxy-Benzaldehyde, 4- Hydroxy- 3, 5- Dimethoxy Benzaldehyde, 3,4-Dimethoxy Benzaldehyde and 3, 4, 5-Trimethoxy Benzaladehyde respectively, in methanol-water (1:1 ratio) at 42 ºC for 8 h. All the azomethines were characterized by UV, IR and thermal elemental analyzer. Anti-bacterial studies were carried out by using Paper disc diffusion method, beef extract is used as bacterial source, chloromphenicol and ketocanazole used  as reference standards, five azomethines gave the following order of  antibacterial activity and order of zone of inhibition was AZM₅ (12mm) > AZM₄ (7mm)  > AZM₃ (10mm) > AZM₁ (9mm) > AZM₂ (8mm) against E. coli and AZM₅ (11mm) > AZM₄ (10mm)  > AZM₃  (9mm) > AZM₁ (7mm) >AZM₂ (6mm) against Bacillus thuringiensis.