SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-(4-ARYL-2-THIAZOLYL) – AND 1-(4-ARYL-2-OXAZOLYL)-3, 5-DIARYL Δ2-PYRAZOLINE DERIVATIVES
AbstractA series of nine 1-(4-aryl-2-thiazolyl)-3, 5- diaryl and six of 1- (4- aryl- 2-oxazolyl)-3, 5- diaryl- 2- pyrazolin derivatives were prepared by reacting 3, 5-diaryl-1- thiocarbamoyl-/or 3, 5- diaryl- 1- carbamoyl- D2– pyrazolines with substituted phenacyl bromide in ethanol. The structures of the synthesized derivatives were confirmed by IR, 1H-NMR, 13C-NMR as well as EIMS spectral data. Some of these derivatives were screened for their antimicrobial activity against Gram-positive, Gram- negative and pathogenic fungi, and showed a significant activity.
Article Information
20
2368-2375
707
1086
English
Ijpsr
Nadia T. A. Dawood
Chemistry Department, Faculty of Science, Girl's, Al-Azhar University, Nasr City, Cairo, Egypt
20 May, 2011
21 August, 2011
23 August, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(9).2368-75
01 September, 2011
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