SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 3, 6- DISUBSTITUTED IMIDAZO [2, 1-B] [1, 3] THIAZOLES
AbstractCyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method against Gram-positive bacterial strains (Bacillus subtillis, Staphylococcus aureus) Gram-negative bacterial strains (Pseudomonas aerugenosa, Kleibsella pneumonia) and fungal strains (Aspergillus niger, Candida albicans). The analogues 1b, 1h and 1i showed promising antimicrobial activity against gram-negative Kleibsella pneumonia; where as analogues 1b, 1e, 1g and 1h showed promising antifungal activity against Candida albicans.
Article Information
30
1537-1542
566KB
1018
English
Ijpsr
V. G. Rajurkar*, R. B. Patil and P. B. Miniyar
Department of Pharmaceutical Chemistry, Sharad Chandra Pawar College of Pharmacy, Dumbarwadi, Otur, Maharashtra, India
09 March, 2011
03 May, 2011
28 May, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(6).1537-42
01 June, 2011
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