SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW HETEROCYCLES CONTAINING NITROGEN AND SULPHURAbstract
The literature survey on 1,2,4-Triazoles and chalcone derivatives revealed that they are endowed with wide variety of biological activities. During the present investigation newer series of chalcone derivatives S-4-(isonicotinamido)-5-(phenoxymethyl) – 4H-1,2,4 triazole-3-yl-3(-4-chlorophenyl) propanethioate (7a-7f) were synthesized by coupling suitably modified 1,2,4-Triazole nucleus with appropriate aryl aldehydes. The structures of the newly synthesized compounds were established by FTIR, 1HNMR and Mass spectral analysis. All the compounds have been evaluated for in vitro antibacterial, antifungal and antitubercular activities. The compounds exhibited weak antibacterial activity only at higher concentrations. Whereas, the antifungal activity results showed that few of the compounds were able to show moderate antifungal potency. The fungi used in the anti-microbial study were found to resistant to the other compounds. The antitubercuar activity results were encouranging as the few compounds were able to possess growth inhibiting properties against the mycobacterium tested i.e the compounds 7b, 7e and 7f possessed the MIC as low as 6.25µg/ml. Even though the compounds failed to possess anti-bacterial and antifungal activity, it is quite interesting to note that most of the compounds were found to be promising biological agents as antitubercular.
Md Akram *, Abdul Sayeed and Syed Yousuf Hussain
MESCO College of Pharmacy Hyderabad (T.S), Andhra Pradesh, India
11 August, 2016
19 October, 2016
06 December, 2016
01 February, 2017