SYNTHESIS AND IN VITRO ANTIPLAQUE ACTIVITY OF CHALCONE, FLAVONOL AND FLAVANOL DERIVATIVESAbstract
Synthesis of chalcone derivatives was carried out by aldol condensation, these 2’-hydroxychalcones were cyclized to 3-hydroxyflavone and 2, 3- dihydroflavan-3-ol derivatives and we also report here there in vitro antiplaque activity. Most of the synthesized compounds were found to be active against Streptococcus mutans. Activity of two 3-hydroxyflavones was found to be higher than that of their corresponding 2, 3- dihydroflavan-3-ol derivatives and chalcone analogues. Investigated compounds having hydroxy group substituents in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antiplaque activity.
Vijayalaxmi Chavan Patil
Government College of Pharmacy, Aurangabad-431005, Maharashtra, India
31 August, 2012
15 October, 2012
30 November, 2012
01 December, 2012