SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL 1, 2, 3, 4-TETRAHYDROQUINAZOLINONE DERIVATIVESAbstract
In the study, we have successfully synthesized N-3 substituted tetrahydroquinazolinone by the reaction of isotonic anhydride with aniline derivatives. Thereafter novel derivative would be subjected to synthesize (1, 2, 3, 4-tetrahydroquinazoline) by Mannich reaction with ciprofloxacin and norfloxacin. These synthesized compounds (2a, 2b, 2c, 2d, 2e, 2f, 2g, and 2h) were characterized by FT-IR, 1H NMR, MASS spectroscopy, and elemental analysis and evaluated for their in-vitro antimicrobial activity and anti-inflammatory activity. The antimicrobial activities of synthesized compounds were evaluated against gram-positive and gram-negative bacteria. Amongst these tested compounds 2c, 2d, 2e, 2f exhibited potent antimicrobial activity than the rest of the compounds. All the synthesized compounds were screened for their anti-inflammatory activity using the carrageenan-induced rat paw edema model and exhibited protection against carrageenan-induced edema.