SYNTHESIS AND SCREENING N-(2, 4′-DIOXO-1, 2-DIHYDRO-3’H-SPIRO [INDOLE-3, 2′-[1,3]THIAZOLIDIN]-3′-YL)-2-HYDROXYBENZAMIDES FOR ANTI-BACTERIAL ACTIVITY
AbstractA novel synthesis of N-(2, 4′-dioxo-1, 2-dihydro-3′H-spiro [indole-3, 2′-[1, 3] thiazolidin]-3′-yl)-2 -hydroxybenzamide derivatives were synthesized by cyclization of isatin hydrazones with thioglycolic acid. The synthesized compounds were characterized by spectral data (IR, 1H-NMR, Mass) and evaluated for antibacterial activity against various strains of bacteria at the concentrations of 200 µg/ml. Among the tested compounds X(i) is highly active against E. coli, X(f) is active against B. subtilis, X(h) is active against S. aureus and X(c) is active against S. typhi.
Article Information
41
3850-3855
686
824
English
IJPSR
N. S. Devi *, B. Srinivas and M. Sarangapani
Medicinal Chemistry Division, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.
nellutlasaritha@gmail.com
23 November 2018
19 March 2019
29 March 2019
10.13040/IJPSR.0975-8232.10(8).3850-55
01 August 2019
Download