SYNTHESIS, ANTITUBERCULAR EVALUATION AND DOCKING STUDIES OF NOVEL BENZIMIDAZOLE ANALOGUESAbstract
A series of (Z)-3-((1H-benzo[d]imidazol-2-yl)methyl)-substituted thiazolidine-2,4-dione (9a-n) have been synthesized and evaluated for their mycobacterium inhibitory activity against Mycobacterium tuberculosis H37Rv strain. The structures of the newly synthesized compounds were characterized by FTIR and NMR spectral analysis. Most of the synthesized compounds showed moderate to good anti-tubercular activity. Among these compounds 9a, 9d, 9f and 9g have displayed good anti-tubercular activity (MIC 6.25 μg/ml). Further, the molecular docking studies were carried out in order to rationalze the biological activity.
D. M. L. Araujo, M. M. Maste *, S. Alegaon and A. Saxena
Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi - 590010, Karnataka, India.
11 December, 2017
03 April, 2018
13 May, 2018
01 September, 2018