SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF NOVEL OXADIAZOLE DERIVATIVES
AbstractNew 5- phenyl- 1, 3, 4- oxadiazole- 2- thiol derivative was synthesized by the ring closure reactions of benzohydrazides with carbon disulphide in presence of ethanolic KOH followed by substitution with secondary amines at 2nd position. All the newly synthesized compounds were characterized by IR, NMR and LC-MASS spectral data. Most of them were tested for their anti-inflammatory and antibacterial activity.
Article Information
19
344-350
594KB
1363
English
Ijpsr
Biswa Mohan Sahoo *, Ravi Kumar B. V. V. and B. U. B. Prasanna kumari
Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Khodasinghi, Berhampur, Orissa, India
28 September, 2010
12 November, 2010
22 January, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(2).344-50
01 February, 2011
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