SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL 2-ARYL BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTIFUNGAL AGENTS
AbstractIn the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The synthesized benzothiazole (BTA) derivatives were characterized physicochemically, by elemental analysis and spectral (IR and 1H-NMR) analysis. The synthesized compounds were screened for their in-vitro antifungal activity against Candida albicans, Aspergillus niger and Cryptococcus neoformans by cup plate method. The results revealed that three compounds namely BTA-3, BTA-9 and BTA-10 have better or equal antifungal activity compared to the standard fluconazole. Further research on benzothiazoles can warrant more consideration on benzothiazoles as prospective antifungal agents.
Article Information
34
4332-4337
568
1182
English
IJPSR
A. Parle and S. Amin *
Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research, New Delhi, Delhi, India.
Shaistamin148@gmail.com
24 January, 2018
08 April, 2018
11 June, 2018
10.13040/IJPSR.0975-8232.9(10).4332-37
01 October, 2018
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