SYNTHESIS, CHARACTERIZATION, BIOLOGICAL AND FLUORESCENT BEHAVIOUR OF METAL (II) COMPLEXES WITH PYRAZOLINE DERIVATIVES

Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2-hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment and electronic spectral data, square planar geometry has been suggested for metal complexes. The binding behavior of the complexes with calf thymus DNA has been investigated by electronic absorption spectra and cyclic voltammetry techniques. The DNA binding constants reveal that all these complexes interact with DNA through intercalation binding mode. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. The antioxidant activities of the complexes showed higher activities. Fluorescent studies reveal that the absorption band is shifted towards visible region indicates that the pyrazoline derivatives of metal complexes may exhibit different emission with respect to suitable substituent present in the pyrazoline structural core. Naphthyl group is responsible for the green colour emission due to its conjugation and electronic delocalization within the molecule and leads to longer wavelength.