SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND ANTHELMINTIC AND ANTI-CANCER ACTIVITY OF PYRAZOLE CONTAIN NOVEL INDOLIN-2-ONE DERIVATIVES
AbstractBackground: Imidazole-5-one scaffold has been predicted in the important synthetic drug analogs, which gave valuable information for treatment and high binding affinity to the multiple receptors helpful drug development. Objective: To synthesize and evaluate the anthelmintic, anticancer, and Insilco docking studies of pyrazole contain novel Indole derivatives (4a-4h). Methods: In the present work, we intended to synthesize pyrazole containing novel Indole derivatives (4a-4h) by a conventional method. Results: All the newly synthesized molecules (4a-4h) were characterized by FTIR, 1HNMR, and Mass spectral analysis. The compounds 4c and 4f showed high anthelmintic activity compared with Albendazole as a standard and the compounds 4b, 4e, 4f, and 4g exhibited good anticancer activity against MCF-7 cell line. In molecular docking research, dock rankings of all the synthesized derivatives ranged from -5.972 (compound 4h) to -3.127 (compound 4d). Conclusion: The literature reveals that Imidazole-5-one derivatives have diverse biological activities and a cytotoxic potential to be explored for newer therapeutic possibilities.
Article Information
19
3404-3413
1610 KB
433
English
IJPSR
Hemalatha Sattu *, Sayeda Hinanaaz and Oleti Navneetha
Department of Pharmaceutical Chemistry, S. N. Vanita Pharmacy Mahavidyalaya, Tarnaka, Secunderabad, Hyderabad, India.
hemalathasattu0@gmail.com
03 November 2022
16 December 2022
02 January 2023
10.13040/IJPSR.0975-8232.14(7).3404-13
01 July 2023
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