SYNTHESIS, CHEMICAL CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINOXALINES
AbstractSubstituted quinoxaline has received considerable attention during the last few years as they are endowed with various biological activities and have a wide range of therapeutic properties. Piperazine has proven its worth in numerous clinically active drugs broader areas of therapeutic index. Hence, biologically important quinoxaline derivatives containing a piperazine moiety and Schiff base scaffolds were prepared. The structures of the synthesized compounds were characterised by elemental analysis, IR, NMR, and Mass spectra. All the prepared derivatives were screened for antibacterial and antifungal activity by disc diffusion method using nutrient agar media against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa, & potato dextrose agar medium for activity against Aspergillus niger and Candida albicans using ciprofloxacin as a standard for antibacterial and clotrimazole as a standard for antifungal activity respectively. Fluoro and trimethoxy-containing derivatives have shown promising activity against gram–ve bacteria P. aeruginosa. Some compounds have shown moderate antifungal and antibacterial activity.
Article Information
50
4244-4253
871 KB
598
English
IJPSR
M. J. Birajdar *, Y. P. Kulkarni, S. M. Sonwane, K. L. Satpute, G. V. Lohiya and B. Rajeeva
Dayanand College of Pharmacy, Latur, Maharashtra, India.
bmahesh1686@gmail.com
03 January 2022
28 September 2022
29 September 2022
10.13040/IJPSR.0975-8232.13(10).4244-53
01 October 2022
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