SYNTHESIS OF 3- (1 – BENZYL – 1H – BENZO [D] IMIDAZOL – 2 – L AMINO) – 2 – (3 – ARYL – 1- PHENYL – 1H – PYRAZOL – 4 – YL) THIAZOLIDIN – 4- ONES AND THEIR ANTIMICROBIAL ACTIVITIES
AbstractReaction of 1- (1- benzyl- 1H- benzo [d] imidazol- 2- yl) hydrazine (1) with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-f) in ethanol yielded the corresponding Schiff bases (3a-f). Further, cyclization of compounds 3a- f with thioglycollic acid in benzene in presence of anhydrous ZnCl2 furnished desired novel compounds 3- (1 – Benzyl – 1h – Benzo [D] Imidazol – 2 – L Amino) – 2 – (3 – Aryl – 1- Phenyl – 1h – Pyrazol – 4 – Yl) Thiazolidin – 4- Ones (4a- f) in 41-65% yield. All the synthesized compounds were screened for antibacterial and antifungal activities. Among the synthesized compounds 3b, 3d, 4a and 4f have shown good activity against bacteria P. aeruginosa, S. aureus and P. vulgaris, where as other compounds have shown moderate to poor activity against all the organisms. The compounds 3a and 3c exhibited good activity against fungal strains A. niger and A. flavus. All remaining synthesized compounds exhibited moderate to poor activity against all the organisms. The structures of synthesized compounds have been established by spectral studies and elemental analysis.
Article Information
6
50-56
464 kB
1173
English
IJPSR
Sharanabasappa B. Patil and Naganna M. Goudgaon*
Department of Studies and Research in Chemistry, Gulbarga University, Gulbarga (Karnataka), India
ngraghu@rediffmail.com
05 March, 2010
20 April, 2010
20 May, 2010
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(6).50-56
01 June, 2010
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