SYNTHESIS OF 4- (4-SUBSTITUTED)-1-(3- SUBSTITUTED- 5, 6-DIHYDRO- [1, 2, 4] TRIAZOLO [3, 4-A] PHTHALAZIN-6-YLAMINO) AZETIDIN-2-ONE DERIVATIVES AS ANTIDIABETIC AGENTS
AbstractIn this research work, numerous molecules that have substituted triazole phthalazine derivatives were obtained using phthalic anhydride as a starting material. It was taken as starting material that gave reaction in the precence of different conditions with different substituted benzoyl chloride that yielded 6 chloro-3 substituted 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazine derivatives (I-V). These intermediates further reacted with substituted benzaldehyde and yielded 4-2-3-Substituted – 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazin-6-yl) substituted hydrazinyl derivatives (VI-X) which were further react with triethyl amine and acetyl chloride yields (XXI-XXX). The antidiabetic effect was investigated using oral glucose tolerance test in normal and non-insulin-dependent diabetes mellitus (NIDDM) in STZ-rat model. In this model Roziglitazone taken as a standard drug for this pharmacological activity.
Article Information
17
3543-3549
649 KB
274
English
IJPSR
Smita Singh *and Pranjal Kumar Singh
S. R. M. Modinagar College of Pharmacy, SRM Institute of Science and Technology, Delhi NCR Campus, Delhi Meerut Road, Modinagar, Uttar Pradesh, India.
smita0082@gmail.com
11 January 2022
25 March 2022
26 April 2022
10.13040/IJPSR.0975-8232.13(9).3543-49
01 September 2022
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