SYNTHESIS OF NOVEL HESPERETIN OXIME ESTERS: A NEW DISCERNMENT IN TO THEIR ANTIOXIDANT POTENTIALAbstract
A series of novel hesperetin oxime esters (3a-l) were synthesized and there in vitro antioxidant potential was examined. Hesperetin oxime 2 was furnished by oximation of hesperetin then subsequently upon esterification with substituted benzoyl chlorides to obtain hesperetin oxime esters (3a-l) in good yields. The structure of compounds was elucidated by elemental analysis, IR, NMR (1H, 13C) and mass spectral studies. Among, the synthesized derivatives compounds (3i-l) showed pronounced antioxidant activity indeed higher than standard butylated hydroxyl anisole (BHA) and ascorbic acid (AA). Compounds with electronegative groups 3a and 3b demonstrated least activity compared to other analogues.
Nagaraja Naik* and Salakatte Thammaiah Harini
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
25 October, 2013
13 December, 2013
24 March, 2014