SYNTHESIS OF THE HETEROCYCLIC HYDROXAMIC ACID DERIVATIVES FOR PDF INHIBITORS AS A ANTIBIOTICS
AbstractPeptide deformylase (PDF) is a mononuclear metal ion protein that is responsible for removing the N-formyl group of nascent proteins found in bacteria and chloroplasts in order for them to become mature proteins. From literature it was found that heterocyclic derivatives containing hydroxamic acid and hydroxyl amine exhibit good antibacterial and PDF inhibitory activity. Heterocycles bearing nitrogen, sulphur, oxygen and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Recently 1,3,4 oxadiazole and 1,3,4 –triazole derivatives received significant attention owing to their diverse range of biological properties particularly being antifungal, antitubercular, antibacterial, antiviral, anticancer and antioxidant. Ethyl-cyano- acetate when treated with sodium hydrate and THF give acetate derivatives, which on further treatment with hydrazine hydrate and various reagent afforded heterocyclic hydroxylamine derivatives
Article Information
25
2483-91
562
1430
English
IJPSR
Priyanka Vishvanath Bandivadekar,* Shraddha A Phadke and Priya Rajput
Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Dist- Thane, Maharashtra, India
priyanka110991@gmail.com
14 December, 2015
25 January, 2016
03 April, 2016
10.13040/IJPSR.0975-8232.7(5).2483-91
01 June 2016
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