TECHNOLOGICAL DEVELOPMENT IN COMPARISON WITH IDEAL FORMULATION OF BCS CLASS IV DRUG – RIFAXIMINAbstract
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of dosage by converting the drug into nanoparticles and superdisintegrant technology; the drug undergoes solubility and gastrointestinal permeability. By adopting these technologies, it achieves by enhancing the disintegration time of drug when comes in contact with water. Here I would like to promote the range of method development technologies improving the solubility and permeability of class IV drugs in rifaximin.
A. D. Paul and P. R. Sri *
Department of Pharmaceutics, Sri Venkateswara University College of Pharmaceutical Sciences, Tirupati, Andhra Pradesh, India.
23 August 2020
17 March 2021
17 May 2021
01 August 2021