THE EFFECT OF CONSTANT LIGHTING ON THE ORGANIZATION OF CIRCADIAN RHYTHMS OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS AT AGE OF 6 MONTHS
AbstractThe effect of constant lighting on the level of some hematological parameters and their daily dynamics was studied in male Wistar rats at the age of 6 months. It was found that staying in constant light for 3 weeks leads to a rise in hematocrit level, mainly due to an increase in the number of red blood cells, while a decrease in the oxygen-transporting properties of these cells is noted. An analysis of the diurnal dynamics of the studied parameters, it was found that the keeping of animals under constant illumination destroys the circadian rhythms of HGB, MCV, RDWc, PCT, MPV, PDWc, and MCHC. The destruction of the circadian rhythms found in control is most likely due to both a decrease in the level of melatonin in constant light and a violation of its own circadian rhythm in the absence of a pacemaker, which role is played by the alternation of light and darkness.
Article Information
69
1933-1938
774
533
English
IJPSR
M. Lyudmila, K. Maria, K. Youri and A. David *
Researching Laboratory of Experimental Biology and Biotechnology, 24 Very Voloshinoyst, Mytischy, Moscow region, Russian Federation.
notbio@mgou.ru.
12 February 2020
27 January 2021
18 February 2021
10.13040/IJPSR.0975-8232.12(3).1933-38
01 March 2021
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