THE ROLE OF β-ENDORPHIN AND C-PEPTIDE IN STREPTOZOTOCIN INDUCED DIABETIC RATS WITH EFFECT OF ACU-TENS AT ZUSANLI (ST36) ACUPOINTSAbstract
Streptozotocin is 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose drug is commonly used to induce diabetes in experimental rats. This study was designed to evaluate the role of β-endorphin and C-peptide in Acu-TENS therapy at Zusanli (ST36) acupoint. Diabetic was induced by Streptozotocin (45mg/kg/body weight) with a single dose of intraperitoneal injection in male albino Wistar rats. The diabetic rats were treated with Acu-TENS electrical stimulation with a pulsed current of low frequency and high intensity at bilateral Zusanli (ST36) acupoint without anesthesia for 60 days, and the effect was compared with pioglitazone (7.5 mg/kg/body weight) treated diabetic rats on fasting blood glucose, β-endorphin & C-peptide levels. The results showed that a significant reduction (p≥0.01) in fasting blood glucose and increased β-endorphin and C-peptide level in Zusanli (ST36) acupoint treated diabetic rats. The anti-diabetic effect of Zusanli (ST36) acupoint may be due to stimulation of Qi (life energy) and regulating the circulation of blood and an increase in insulin secretion through the mediation of β- endorphin.
R. Subbulakshmi * and G. Sivakumar
Department of Anatomy, Vivekanandha Dental College for Women, Tiruchengode, Namakkal, Tamil Nadu, India.
15 December 2019
10 April 2020
23 November 2020
01 December 2020