TO COMPARE THE EFFECTS OF DEXMEDETOMIDINE (WITHOUT BOLUS DOSE) AND PROPOFOL (SEDATIVE DOSE) ON ATTENUATION OF HEMODYNAMIC CHANGES DURING LAPAROSCOPIC SURGERIESAbstract
Introduction: Laparoscopic surgery is one of the most important diagnostic and therapeutic tools in the present surgical era. Laparoscopic surgeries require insufflation of the abdomen with some gas; usually, Carbon Dioxide is called pneumoperitonium, which induces pathophysiologic changes that complicate anesthetic management. To prevent and counteract these effects, appropriate monitoring and pharmacological interventions are required. Material and Method: In an observational study, sixty (60) patients of ASA physical status I or II aged between 18-60 years of age, of either sex scheduled for elective laparoscopic surgeries under general anesthesia, were observed. Inj. Dexmedetomidine infusion and Inj. Propofol infusion started at a different dose. Results: Both the drugs maintain hemodynamic stability during laparoscopy but at the time of extubation propofol group showed rise in parameters while dexmedetomidine patients were calm. Dexmedetomidine without bolus, as infusion only does result in attenuation of hemodynamic responses. Omitting the bolus dose avoided the undesirable hemodynamic effects like bradycardia and hypotension. Conclusion: The infusions of a sedative dose of dexmedetomidine and propofol during laparoscopic surgery attenuate hemodynamic response to pneumoperitoneum and maintain hemodynamic stability. Dexmedetomidine can be used safely and effectively for attenuation of hemodynamic changes in laparoscopic surgeries and is very effective in the control of heart rate and systolic blood pressure changes.
P. P. Malam *, A. Gargiya, A. Amin and R. P. Malam
Department of Pharmacology, PDU Medical College, Rajkot, Gujarat, India.
14 February 2020
20 October 2020
26 October 2020
01 February 2021