TO CORRELATE LEVELS OF TNF-α, INSULIN, INSULIN RESISTANCE, ANTIOXIDANT ENZYMES AND LIPOPROTEIN PROFILE IN OBESE WITH TYPE 2 DM SUBJECTS

Obesity has become a matter of quality to health care administrators. The busy lifestyle of people made them prefer fast food instead of taking healthy food. But the people are not aware that fast food habits convert to diseases like obesity, type 2 diabetes mellitus (T2DM), dyslipoproteinemia etc. This case-control study was carried out in the Department of Biochemistry in collaboration with the Department of General Medicine, Madhav Prasad Tripathi Medical College, Siddhartnagar to explore the status of blood sugar fasting (BSF), tumor necrosis factor-α (TNF- α), Insulin, Insulin resistance, antioxidant enzymes and lipoprotein profile by standard spectrophotometric kit methods, as well as anthropometric measurements, blood pressure (BP) with the help of suitable instruments and equipment’s in Control group and Obese with T2DM group. A marked impairment observed in levels of lipoprotein profile accompanied by an increase in the lipids and apo-protein levels of serum β lipoproteins, lipid peroxide, Insulin and Insulin resistance, blood pressure, anthropometric measurements following the decrease in lipid and apo-protein constituents of α lipoprotein. Also observed in decrease of levels of serum-reduced glutathione as well as the level of antioxidant enzymes in the obese with T2DM group with respect to control group. Thus, it is clear that obesity with T2DM is a risk factor for diabetic dyslipoproteinemia and coronary artery disease (CAD) in patients suffering from obese with T2DM.