TOXIC IMPACT OF λ- CYHALOTHRIN ON DNA AND RNA CONTENTS OF THE FISH CTENOPHARYNGODON IDELLA

The synthetic pyrethroids used in agriculture also absorb rapidly via different routes and slowly accumulate into various vital tissues and cause adverse effects on the health status of animals.  It leads to produce a number of biochemical changes at the level of nucleic acids. The freshwater fish Ctenopharyn godonidella was exposed to sublethal concentrations (1/10th of LC50 value) of λ- cyhalothrin 5% EC for a period of 1, 4, 8 and 12 days to study the toxic impacts on DNA and RNA contents in various organs such as gill, muscle liver-kidney, and brain. In control fish, DNA content was in the order of Muscle (35.78)> Liver (34.17) > Kidney (28.74) > Brain (25.60) > Gill (18.71) and RNA was in the order of Kidney (37.15) > Muscle (36.45) > Liver (32.68) > Brain (28.15) > Gill (22.56). In the present study under sublethal concentrations of λ- cyhalothrin on day 12the percent depletion of DNA content in the test tissues were in the order of: Brain (21.43) > Gill (16.36) > Muscle (32.18) > Kidney (26.24) > Liver (31.74) and RNA content in the order of Liver (23.33)> Gill (17.54) > Brain (22.41) > Muscle (31.18) > Kidney (32.56). In the present study, results reveal that λ- cyhalothrin caused variability in the nucleic acids in different tissues and are dose-dependent. Inhibition of DNA synthesis thus might affect both proteins and amino acid levels by decreasing the level of RNA in protein machinery.