TOXICITY AND ANTIHYPERTENSIVE ACTIVITY OF LIPPIA MULTIFLORA EXTRACTS IN THE DIFFERENT REGIONS OF BENIN

The objective was to study the antihypertensive effects of the aqueous decoctycrude of Lippia multiflora from the region of Djidja at a dose of the plant as well as the effects of this extract on some biochemical parameters in the rat were made hypertensive by 500 mg/kg of body weight during the 14 days and were treated with losartan potassium at a dose of 100 mg/kg of body weight, of L-NAME at a dose of 40 mg/kg of body weight between 150 and 250g. Administration of L-NAME was caused a significant increase in PAS, PAD, and PAM in rats from 142.4±19.89 mmHg (J0) to 172.4±15.95 mmHg (J8) and 122.8±7.05 mmHg (J0) to 138.6±36.39 mmHg (J8), from 93.8±5.42 mmHg (J0) to 137.5±11.90 mmHg (J8) and from 92.5±4.55 mmHg (J0) to 136.75±7.68 mmHg (J8) and 109.25±15.52 mmHg (J0) to 159.75±27.80 mmHg (J8) and from 99.8±13.39 mmHg (J0) to 151.25±8.13 mmHg (J8) respectively for the positive control batch and the batch subsequently were treated with the raw extract). That of the crude extract from (J8) to (J29) was caused a significant decrease in SBP, PAM and PAD in the rats, dropping from 140±5 mmHg (J8) to 122.4±15.32 mmHg (J29), from 151.25±8.13 mmHg (J8) to 114±19.12 mmHg (J29) and from 136.75±7.68 mmHg (J8) to 99.8±14.82 mmHg (J29) respectively. These values are significantly lower than that of untreated rats, which was 150.5±10.40 mmHg (J29).