TOXICOLOGICAL ASSESSMENT OF CONSUMPTION OF BENZENE-POLLUTED WATER ON THE HEART AND BLOOD OF ALBINO RATS
AbstractThe long-term effects of daily consumption of benzene-contaminated water over a period of Sixty-five days on rats’ cellular system were inspected. Haematological parameters such as haemoglobin, packed cell volume etc were determined. Standard enzyme assays were conducted on some enzymes (alkaline phosphatase, acid phosphatase and lactate dehydrogenase) activities of the heart and serum. Significantly lower (P<0.05) enzymes activities were observed in the heart of test rats relative to control. Conversely, enzymes activities in the serum significantly increased. The white blood cell of test rats was found to be 11.3±0.5 while that of control was 9.8±0.6 suggesting infection in the test rats. Haemoglobin, red blood cell count and packed cell volume of test rats were found to be significantly lower (P<0.05) than that of control which may be indicative of anaemia. It could be inferred therefore, that consumption of benzene-contaminated water could pose serious health problems such as heart failure and abnormal haematological parameters.
Article Information
36
572-577
392KB
1031
English
IJPSR
Aanuoluwa James Salemcity *, Olalekan Adeyemi , Titilope Ayoola Iyanda and Olakunle Oladimeji
Biochemistry Department, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria
xityglory@gmail.com
17 September, 2013
29 October, 2013
23 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).572-77
01 February, 2014
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