TOXICOLOGICAL CHRACTERIZATION OF BRHANMANJISTHADI KVATHA CURNA (BRH) ON THE BASIS OF TOTAL PROTEIN AND ALBUMIN CONTENT, LIPID PROFILE, LIVER FUNCTION, KIDNEY FUNCTION, SERUM URIC ACID AND ENZYMATIC PROPERTY IN RATS’ PLASMA AFTER CHRONIC ADMINISTRATION

Brhanmanjisthadi Kvatha Curna (BRH) an Ayurvedic preparation, is used as a traditional medicine in filariasis in the northern part of the country. After 45 consecutive days of chronic administration of the BRH preparation in rats its toxicological aspects was studied. In the study the total protein content in the plasma was increased (2.80 %) in BRH treated male rats in comparison to their control male groups. The result showed no significant difference between the control and the BRH treated groups, yet the increase was noticeable (p=0.072). But the albumin content was significantly (p<0.001) increased (17.11 %) in BRH treated male rats & the increase was statistically very highly significant. In the female rats group the total protein (6.80 %) and the albumin content in the plasma were also increased in comparison to their control groups. A statistically very highly significant (p<0.001) increase was noted (15.09 %) only in the case of albumin. In this investigation, none of the changes in terms of the Lipid profile, namely Triglycerides (2.18 % decr.), total Cholesterol (0.78 % decr.), VLDL (3.77 % incr.), LDL (4.91 % decr.) and HDL (2.61 % decr.) were significantly different from their corresponding control values in male rats. Similarly, in female rats, no significant change regarding the Lipid profile (Triglycerides 2.18 % decr., total Cholesterol 1.22 % decr., VLDL 3.90 % incr., LDL 5.35 % decr. and HDL 2.61 % decr.) was found. In the male rats there was a statistically a very highly significant decrease (39.65 %) in the Bilirubin content in the plasma. In the female rats there was a statistically very highly significant increase (41.16 %) in the Bilirubin content in the plasma. In the male rats there was a decrease in both the Creatinine and the Urea content in the plasma. But a statistically a very highly significant (p=0.001) decrease (14.88 %) was noted only in the case of the Urea content in the plasma. The decrease (6.40 %) was observed non significant (p=0.152) with Creatinine. In the female rats there was a statistically very highly significant (p=0.001) decrease in both the Creatinine (25.97 %) and the Urea (16.35 %) content in the plasma. It was observed that about 6.18 % increase which is statistically significant (p<0.039)  in plasma Uric acid content of BRH treated male rats in comparison to their control male rats whereas the female rats showed a comparatively insignificant (p=0.118) (3.83 %) increase in concentration  of the Uric acid level. In this investigation, none of the changes in terms of the sGPT (0.10 % incr.), sGOT (0.33 % incr.) and ALP (0.58 % incr.) activities were significantly different from their corresponding control values in male rats. Similarly, in female rats, no significant change regarding the enzyme activities of sGPT (0.13 % incr.), sGOT (0.26 % decr.) and ALP (0.53 % incr.) were noted when compared to their corresponding control values in female rats