TRANSFEROSOME: LATEST UPDATESAbstract
Poor patient compliance is a frequent problem in daily clinical practice. The unfavorable pharmacokinetic of the drug, the inconveniences of the standard form of such drug application and the side effects due to the administration route often are the reasons for this. The high and self-optimizing deformability of typical composite transferosomes membrane, which are adaptable to ambient tress allow the ultra-deformable transferosomes to change its membrane composition locally and reversibly, when it is pressed against or attracted into narrow pore. Transferosomes possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. Transferosomes can deform and pass through narrow constriction (from 5 to 10 times less than their own diameter) without measurable loss. This high deformability gives better penetration of intact vesicles. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormone, anticancer, insulin, gap junction protein, and albumin.
V. Dilip Kumar, B. Saraswathi and N. Prudvi Kanth
Trinity College of Pharmaceutical Sciences, Jangoan College of Pharmaceutical Sciences, Andhra Pradesh, India
19 June, 2013
19 August, 2013
21 October, 2013
01 November, 2013