ULTRASOUND SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES OF FE (III) COMPLEXES OF Β-DIKETONES
HTML Full TextULTRASOUND SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES OF FE (III) COMPLEXES OF Β-DIKETONES
Aakash S. Singare, Jaiprakash S. Dargad and Nanda S. Korde *
Department of Chemistry & Industrial Chemistry, Dayanand Science College, Latur, Maharashtra, India.
ABSTRACT: Consistently the preparation of transition metal complexes of β-diketones has been (and it still is) an area of the highest interest for inorganic and organic chemists, as can be inferred considering the quantity and diversity of research developed in this field. 1,3- Diketones are wide range of valuable molecules including several types of carbocycles and heterocycles hence have high interest. In fact, excessive amount of therapeutical uses are associated with these 1,3- Diketone compounds. The present work is based mainly on the ultrasound irradiation synthesis of various β-diketone ligands and their Fe (III) complexes. At ambient temperature, the clinically active and functionalized various β-diketones has been synthesized from Baker–Venkataraman transformation and its Fe (III) complexes has been prepared and characterized by physical, spectral and analytical data. The different spectroscopic analysis like Mass, 1H-NMR, 13C-NMR, IR, UV and elemental analysis were done. The functionalized beta-diketones showed a certain behaviour and behaved as bidentate ligand and co-ordinate with the transition metal atom through beta-diketo system. The complexes have general formula [ML2]. The biological activities like antibacterial and antifungal were performed for the synthesized compounds. The biological screening data indicated that the transition metal complexes are more potent antibacterial, antifungal and antioxidant agents than the parent functionalized beta diketones against different species of bacteria and fungi. This constitutes a new group of compounds. The thermal stability of the newly synthesized metal complexes has been studied.
Keywords: β-diketones, Transition metal complexes, Ultrasound irradiation, Baker-Venkataraman transformation, Mass, 1H-NMR, 13C-NMR, IR, UV, Antifungal, Antibacterial
INTRODUCTION: For almost a century the chemistry of 1,3-diketones has attracted the attention of scientists. Diketones are the key intermediates for the synthesis of heterocycles such as isoxazole 1, flavones 2, pyrimidine 3, triazole 4, pyrazole[5] and benzodiazepines 6. β-diketone for eg. Anabena β-diketone hydrolase have some enzymatic activities 7, rare earth doped complexes of β-diketone were studied as high density optical recording materials for blue optoelectronics 8. β-diketone lanthanide complexes are studied for their optical properties like fluorescence 9, 10 and electroluminescence 11.
β-diketone are clinically important molecules hence they having some biological activities such as antiviral 12, anti-tumor 13-14, anticancer 15, insecticidal 16, antioxidants 17 and antibacterial 18. Many naturally occurring 1,3-diketones such as dibenzoylmethane (DBM-1) has been the therapeutic option for cancer treatment, as well as for anti-inflammatory and dementia, has recently reviewed 19. On the other hand, some novel 3,4-disubstituted pyrazole derivatives have shown antifungal and antibacterial properties 20. Australifungin, isolated from sporomiella vities of Fe (III) ustralis shown a prominent antifungal activity 21. Additionally the chemical structures, of β-diketone can be considered as excellent drug, candidate showing multi-target potency. For instance, asymmetrical 1,3-diketones with anti-inflammatory and anti-cancer activities, synthesized by reaction between N-acyl benzotriazoles and ketones based on soft enolization 22. Thus β-diketones act as very important median to various heterocyclic compounds 23 and also used as chelating agents 24. It is used as a extractant for copper ions 25. The research being energizing by the versatility and these compounds as laser chelates 26, chemical and photochemical catalysts 27, shift reagents 28, extraction agents 29. Studies on the β-diketone and their metal complexes are being of more and more interest to the chemists and biochemists 30. This paper reports the synthesis of various ligands by Baker-Venkatraman re-arrangement 31 and their Fe (III) complexes, spectral analysis and antimicrobial screening of the compounds.
EXPERIMENTAL METHODS:
Preparation of 2-acetylphenyl, 4-methoxy benzoate:
Compound 1: To the mixture of 2-hydroxy acetophenone (1.36g, 0.01mol) and 4-methoxy benzoic acid (1.52g,0.01mol), a dry pyridine (5-6ml) and phosphorus oxychloride (POCl3) about 1ml were added drop wise at 0°C with the constant stirring. Then reaction mixture was kept in ultrasonicator for 4-5 hrs. After completion of the reaction (monitored by TLC), the reaction mixture was then cooled and poured on cold water containing HCl (1M) and solid product obtained was filtered and washed with cold methanol (10ml) and after that with distilled water. It was then re-crystallized from ethanol. A similar procedure was adopted for the preparation of other compounds namely:
- 2-acetylphenyl, 4-ethoxy benzoate
- 2-acetylphenyl, 4-bromo benzoate
- 5-chloro, 2-acetylphenyl, 4-methoxy benzoate
- 5-chloro, 2-acetylphenyl, 4-ethoxy benzoate
- 5-chloro, 2-acetylphenyl, 4-bromo benzoate
Preparation of 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl) propane-1,3-dione [L1]:
Compound 2: For the preparation of 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)propane-1,3-dione compound 1, (2.70g,0.01mol) was dissolved in dry pyridine (about 10ml) and to this powdered KOH (1.12g,0.02mol) was added and the reaction mixture was irradiated in ultrasound for 1-2hrs. After completing the reaction (monitored by TLC), the mixture was poured on in ice-cold water and acidified with conc. HCl. The solid obtained was then filtered off and it was re-crystallized from absolute alcohol.
Yield: 85% M.P: 115°C. FTIR(KBr)cm-1: FT-IR (KBr) cm-1: 2912.98 (-OH), 1708.01 (C=O), 1487.74 (Ar C=C).1H-NMR (300 MHz, CDCl3,-d6): δ =7.9 (d, 3H, Ar-H), 6.8 (m, 5H, Ar-H),7.4 (q , 1H,=CH-), 3.9 (s,3H, OCH3) ,12.2 (s, 1H, OH), 15.9 (s, 1H, Enolic-OH), 13C-NMR (300 MHz, CDCl3), δ 190.0(s, C-1,C=O), 92.8 (s, C-2,-CH=), 185.1(S,C-3), 126.0(d, C-1’,C-1’’), 162.8 (s,C-2’), 118.4 (s,C-3’), 135.8 (s,C-4’), 119.3 (s,C-5’), 128.7 (s, C-6,’), 128.0 (d, C-2’’,C-6’’), 114.1(d, C-3’’, C-5’’), 162.0 (s, C-4’’), 55.8 (s,C-7’’,0CH3). UV/Vis (DMSO) nm: 370,410; EC-MS: 270.28 (M+23).
A similar procedure was adopted to prepare following ligands:
- 1-(2-hydroxyphenyl)-3-(4-ethoxyphenyl) propane-1,3-dione,
- 1-(2-hydroxyphenyl)-3-(4-bromoyphenyl) propane-1,3-dione,
- 1-(5-chloro,2-hydroxyphenyl)-3-(4-methoxyphenyl).propane-1,3-dione,
- 1-(5-chloro,2-hydroxyphenyl)-3-(4-ethoxyphenyl) propane-1,3-dione,
- 1-(5-chloro,2-hydroxyphenyl)-3-(4-bromoyphenyl)propane-1,3-dione.
Preparation of Fe (III) Complex: The mixture of compound 2 (5.40g, 0.02mol), anhydrous Fe (III) nitrate (4.04g, 0.01mol) and 20 ml anhydrous ethanol was added and irradiated for 1-2 hrs under ultrasound. The obtained solid was washed with hot ethanol and recrystallised from ethyl acetate. The brownish crystals of Fe (III) β- diketonate obtained. Yield: 78%; mp: 348°C. A similar procedure was adopted to prepare Fe (III) complexes of remaining ligands.
SCHEM 1: SYNTHESIS OF 1-(2-HYDROXYPHENYL)-3-(4-METHOXYPHENYL) PROPANE-1, 3-DIONE AND Fe(III) COMPLEX
RESULT AND DISCUSSION:
Antimicrobial Activity: Antimicrobial screening 32-33 is done by using the method called Kirby Baur’s disc diffusion technique using dimethyl sulfoxide as a solvent. The streptomycin was used as a standard and the method were tested against bacteria such as Staphylococcus aureus and Bacillus subtilis (Gram +ve); Escherichia coli (Gram-ve) and against fungi like Fusarium oxysporum and Aspergillus niger. A uniform suspension of a test organism of 24 hours old cultures was prepared in test tube holding a sterile saline solution. A 20 ml sterile Muller-Histon agar was then added in each of the petri plates. The plates were rotated to ensure the uniform mixing of micro-organism in agar medium which was then allowed to solidify. Then by keeping sterile Whatman filter paper disc were dipped in the solution of each compound and placed on labeled plates. Then these petri plates were kept in refrigerator for half an hour for diffusion then bacterial cultured plate incubated at 37°C for 24 hours and fungal cultured plate were incubated at 30°C for 24 hours. The antibacterial activity was examined by measuring the diameter of inhibition zone formed. The zones were measured in terms of mm. The results of antimicrobial activity of synthesized compounds have shown that the transition metal complex reveals the greater antimicrobial activity than that of the ligand. The observed data of antimicrobial activity of synthesized compounds and the standard is given in Table 1.
TABLE 1: DATA OF ANTIMICROBIAL ACTIVITY OF LIGANDS (L1-L6) WITH THEIR FE (III) COMPLEXES
Compounds | Zone of Inhibition in mm | ||||
Antibacterial activity | Antifungal activity | ||||
Bacillus subtilis | Staphylococcus aureus | E. coli | Fusarium oxysporum | Aspergillus niger | |
L1
ML1 |
6
8 |
6
7 |
7
8 |
7
7 |
7
9 |
L2
ML2 |
7
7 |
7
8 |
6
8 |
8
7 |
7
7 |
L3
ML3 |
7
7 |
7
6 |
7
8 |
7
8 |
7
6 |
L4
ML4 |
7
7 |
8
8 |
6
8 |
7
6 |
6
|
L5
ML5 |
7
8 |
6
7 |
7
8 |
7
6 |
7
7 |
L6
ML6 |
7
8 |
7
7 |
7
6 |
7
7 |
7
8 |
stryptomycin | 6 | 6 | 7 | 6 | 6 |
TABLE 2: ANALYTICAL DATA OF Fe (III) COMPLEXES
Complex | Molecular formula | Mol. Wt | % Found (calculated) | |||||
C | H | Br | Cl | O | Fe | |||
ML1 | C32H36FeO12 | 632 | 60.97
(60.11) |
4.80
(4.97) |
---- | ---- | 25.38
(25.11) |
8.86
(8.17) |
ML2 | C33H38FeO12 | 660 | 62.02
(61.08) |
5.20
(5.17) |
---- | ---- | 24.30
(24.01) |
8.48
(7.35) |
ML3 | C32H36FeBrO12 | 730 | 49.48
(49.41) |
3.32
(3.15) |
21.95
(21.30) |
---- | 17.58
(17.04) |
7.67
(7.01) |
ML4 | C32H36FeClO12 | 701 | 54.96
(54.41) |
4.04
(4.12) |
----- | 10.14
(10.02) |
22.88
(22.30) |
7.99
(7.12) |
ML5 | C33H38FeClO12 | 729 | 56.14
(55.23) |
4.43
(4.47) |
---- | 9.75
(9.13) |
22.00
(21.45) |
7.68
(7.07) |
ML6 | C32H36FeClBrO12 | 799 | 45.21
(45.15) |
2.78
(2.01) |
20.05
(19.71) |
8.90
(8.19) |
16.06
(15.77) |
7.01
(6.91) |
TABLE 3: PHYSICAL CHARACTERISTICS OF LIGANDS WITH THEIR Fe (III) COMPLEXES
Sr. no. | Compounds | % Yield | Colour | Melting point |
1 | ML1 | 78 | Blackish brown | 348°C |
2 | ML2 | 82 | Blackish brown | 324°C |
3 | ML3 | 79 | Blackish brown | 330°C |
4 | ML4 | 84 | Blackish brown | 319°C |
5 | ML5 | 81 | Blackish brown | 338°C |
6 | ML6 | 80 | Blackish brown | 345°C |
Molar Conductance and Magnetic Susceptibility: The new synthesized ligands and their Fe(III) complexes are in the solid state and are very stable at room temperature. The synthesized ligands are soluble in common organic solvents, and their Fe(III) complexes are soluble in DMF and DMSO. Due to the continuous variation results, it is concluded that the stoichiometry of the complexes are conformable with the ratio 1:2 for metal to ligand. The molar conductivity of all complexes were measured in dimethyl formamide and values were observed between 61.3-67.2 ohm-1cm2 mol-1 indicating their non-electrolytic nature 34.
TABLE 4: MOLAR CONDUCTANCE AND MAGNETIC SUSCEPTIBILITY OF Fe(III) COMPPLEXES
Sr. no. | Complex | Molar conductance | Xdia × 10-6 | μeff (B.M.) |
1 | ML1 | 61.3 | -513.15 | 5.55 |
2 | ML2 | 62.4 | -564.21 | 6.01 |
3 | ML3 | 67.2 | -319.66 | 5.62 |
4 | ML4 | 63.1 | -489.25 | 5.92 |
5 | ML5 | 65.6 | -535.11 | 6.37 |
6 | ML6 | 64.8 | -521.17 | 6.06 |
Spectral Characterizations:
TABLE 5: INFRARED SPECTRAL DATA, UV AND MASS OF SYNTHRESIZED COMPOUNDS
Sr. no. | Compound | IR (cm-1) | UV | Mass spectra | |||||
ѵ(C=O) | v(C=C) | ѵ(OH) | C-Br bond | M-O | λmax for >C=O (nm) | Donor atom | |||
1 | L1 | 1708 | 1599 | 2912 | 410,370 | 270.28 | O-O | ||
ML1 | 1682 | 1602 | 3187,3290 | 620 | --- | --- | --- | ||
2 | L2 | 1702 | 1565 | 2921 | ---- | ---- | 410,360 | 284.3 | O-O |
ML2 | 1692 | 1599 | 3243,3526 | ---- | 562 | ---- | ---- | ---- | |
3 | L3 | 1718 | 1558 | 3069 | 1223 | ---- | 412,360 | 319.15 | O-O |
ML3 | 1685 | 1580 | 3271,3180 | ---- | 575 | ---- | ---- | ---- | |
4
|
L4 | 1741 | 1591 | 2919 | ---- | ---- | 412,374 | 304.73 | O-O |
ML4 | 1670 | 1597 | 3216,3417 | ---- | 562 | ---- | ---- | ---- | |
5 | L5 | 1720 | 1605 | 2977 | ---- | ----- | 410,370 | 318.75 | O-O |
ML5 | 1650 | 1605 | 3244,3412 | ---- | 600 | ---- | ---- | ---- | |
6 | L6 | 1743 | 1587 | 2916 | 1239 | ---- | 410,360 | 353.6 | O-O |
ML6 | 1690 | 1634 | 3216,3072 | ---- | 606 | ---- | ---- | ---- |
1H-NMR: 1H-NMR spectra of β-diketones showed two proton signals at a range δ15.4-17.7 ppm and δ 11.9-12.2 ppm which corresponds to enolic proton and phenolic proton adjacent to carbonyl group. It confirms the formation of β-diketone. The compound in enolic form is more stable than that of ketonic one 35.
13C-NMR: In the 13C-NMR spectra all synthesized β-diketone ligands gives characteristic peak at ketonic carbon C1, C2 and enolic carbon C3 are in the ranges δ 189.5-193.8, δ 91.2-93.1 and δ 176.8-185.1 ppm confirms the formation of β-diketone 36.
TABLE 6: INDUCED X-RAY DIFFRACTION OF COMPLEX Fe-L1
Peak no. | 2θ(obs) | 2θ(cald) | d(obs) | d(cald) | Miller indices of planes
h k I |
Intensity (%) | ||
1 | 25.796 | 25.963 | 3.4509 | 3.4291 | 1 | 0 | 1 | 40.0 |
2 | 27.298 | 27.015 | 3.2643 | 3.2979 | -1 | 0 | 2 | 35.1 |
3 | 28.988 | 28.996 | 3.0777 | 3.0769 | -1 | 1 | 2 | 23.1 |
4 | 30.697 | 30.708 | 2.9101 | 2.9091 | -1 | 2 | 1 | 41.1 |
5 | 32.094 | 32.453 | 2.7866 | 2.7566 | 0 | 1 | 3 | 28.2 |
6 | 38.012 | 37.655 | 2.3652 | 2.3869 | 0 | 3 | 2 | 30.0 |
7 | 57.077 | 56.882 | 1.6123 | 1.6174 | 0 | 2 | 5 | 31.2 |
8 | 61.199 | 61.229 | 1.5132 | 1.2125 | 1 | 3 | 4 | 30.1 |
9 | 64.311 | 64.292 | 1.4473 | 1.4477 | 1 | 5 | 2 | 24.1 |
10 | 66.287 | 66.419 | 1.4088 | 1.4064 | 0 | 6 | 1 | 22.0 |
TABLE 7: INDUCED X-RAY DIFFRACTION OF COMPLEX Fe-L3
Peak no. | 2θ(obs) | 2θ(cald) | d(obs) | d(cald) | Miller indices of planes
h k I |
Intensity (%) | ||
1 | 21.700 | 21.960 | 4.0921 | 4.0443 | -1 | 0 | 0 | 60.0 |
2 | 23.492 | 23.144 | 3.7839 | 3.8399 | 0 | 2 | 1 | 55.1 |
3 | 28.192 | 28.012 | 3.1628 | 3.1827 | 1 | 1 | 1 | 45.1 |
4 | 30.302 | 30.400 | 2.9472 | 2.9379 | -1 | 2 | 0 | 42.2 |
5 | 34.115 | 34.313 | 2.6260 | 2.6113 | -1 | 0 | 3 | 40.5 |
6 | 35.597 | 35.930 | 2.5200 | 2.4974 | -1 | 1 | 3 | 35.3 |
7 | 37.708 | 37.655 | 2.3835 | 2.3869 | 0 | 3 | 2 | 30.1 |
8 | 55.878 | 55.773 | 1.6440 | 1.6469 | 1 | 2 | 4 | 32.1 |
9 | 79.082 | 79.075 | 1.2099 | 1.200 | -2 | 4 | 5 | 30.6 |
10 | 85.107 | 85.087 | 1.1390 | 1.1392 | -3 | 2 | 5 | 28.1 |
Thermogram of Fe(III) Complexes: In nitrogen atmosphere using α-Al2O3 as reference, the simultaneous TG/DT analysis of a complex of Fe (III) was studied. At the temperature range 185-200°C the thermogram curve of Fe (III) complex shows weight loss 7.40% (calcd. 7.78%) and at 190°C it shows keen endotherm which distinctly designate removal of two coordinated water molecules 37. The anhydrous complex revealed a single step decomposition with 70% mass loss and a broad endothermic peak in the DTA at the temperature range from 210°C to 820°C. The Fe2O3 is obtained as the end product.
CONCLUSION: In the present work ligands and its Fe(III) complexes were synthesized. On the basis of their spectral analysis the structures were elucidate. Due to presence of enolic proton and phenolic proton adjacent to carbonyl group, the prepared diketones having characteristics peaks of 1H NMR and 13C NMR spectra. It has been suggested that the antibacterial and antifungal activity of ligands (L1)–(L6) increased upon chelation/coordination with the transition of metal atoms. By coordinating metal ion with ligands, the chelation process reduces the polarity of metal ion which increase the lipophilic nature of the metals and enhanced its penetration through the lipoid layer of cell membrane of the microorganism. Also, it has been suggested that beta-diketones having combined two or more pharmacophore sites played an important role in antibacterial and antifungal activity. This functionalized system may be responsible for the enhancement of hydrophobic character and liposolubility of the molecules.The synthesized compounds were screened in vitro for antifungal, antibacterial and found to be promising candidates as new antibacterial, antifungal agents.
ACKNOWLEDGEMENTS: One of the authors is thankful to Head, Department of chemistry, Dayanand Science College, Latur for providing the laboratory facility and Head, Department of microbiology, Dayanand Science College, Latur for providing the laboratory facility for evaluation of biological studies.
CONFLICTS OF INTEREST: Nil
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Singare AS, Dargad JS and Korde NS: Ultrasound synthesis, spectral characterization and antimicrobial activities of Fe (iii) complexes of β-diketones. Int J Pharm Sci & Res 2023; 14(12): 5824-30. doi: 10.13040/IJPSR.0975-8232.14(12).5824-30.
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Article Information
29
5824-5830
624 KB
156
English
IJPSR
Aakash S. Singare, Jaiprakash S. Dargad and Nanda S. Korde *
Department of Chemistry & Industrial Chemistry, Dayanand Science College, Latur, Maharashtra, India.
nandineekorde0@gmail.com
26 April 2023
08 July 2023
28 July 2023
10.13040/IJPSR.0975-8232.14(12).5824-30
01 December 2023