UV SPECTROPHOTOMETRIC AND RP-HPLC ESTIMATION OF DRUG ASENAPINE IN TABLET DOSAGE FORM
AbstractAsenapine in Tablet dosage form is used as antipsychotic agent. Literature revealed that there is no single method for the simultaneous estimation of this drug in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive UV spectrophotometric and RP-HPLC methods. The simultaneous estimation of UV method is based on the principle of additivity of absorbance, for the determination of Asenapine in tablet formulation. The absorption maximum of the drug was found to be 270.0 nm in methanol. For RP-HPLC mobile phase is a mixture of acetonitrile and 0.1 M phosphate buffer (pH = 3.2) in the ratio of 65:35 v/v and detection wavelength is 270 nm. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.
Article Information
41
3080-84
398
1259
English
IJPSR
A. A. Borkar * and N. J. Gaikwad
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur, India
udpsaab@gmail.com
23 February, 2016
17 March, 2016
04 May, 2016
10.13040/IJPSR.0975-8232.7(7).3080-84
01 July 2016
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