UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DICLOFENAC SALT AND EPERISONE HYDROCHLORIDE IN BULK AND CAPSULE DOSAGE FORM
AbstractThe present paper describes a new, simple, accurate, environmentally friendly, economic spectrophotometric method for simultaneous estimation of Diclofenac salt and Eperisone HCl in bulk and Capsule Dosage Form. Acetate buffer pH5.5 was used as solvent. The wavelength selected for analysis is 276nm & 261.20nm for estimation of Diclofenac Salt and Eperisone HCl respectively. Beers law was obeyed in the range of 10-50µg/ml and 5-25µg/ml with correlation coefficient of0.999 and 0.998 respectively. Detection limit and quantification limit were found to be 0.6031g/ml and 1.87g/ml for Diclofenac sodium and 0.208g/ml and 0.6302g/ml for Eperisone hydrochloride respectively. The developed method was found to be simple, accurate, precise and reproducible. Assay results were found to be 99.20% and 101.13% for Eperisone hydrochloride and Diclofenac sodium respectively. The value of relative standard deviation and percentage recovery was found to be satisfactory. The obtained results proved the method can be used for routine analysis of Diclofenac sodium and Eperisone Hydrochloride in capsule dosage form. The method where tested and validated as per ICH guidelines.
Article Information
31
3810-14
340
2078
English
IJPSR
Kiran K. Dhokale*, Deepak D. Deore and Madhuri A. Nagras
Sinhgad College of Pharmacy, Department of Quality Assurance Techniques, Vadgaon (Bk.), Pune, Maharashtra, India
kirankdhokale@gmail.com
09 April, 2016
27 May, 2016
13 June, 2016
10.13040/IJPSR.0975-8232.7(9).3810-14
01 September 2016
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