UV-SPECTROSCOPIC METHOD FOR ESTIMATION OF TIEMONIUM METHYLSULFATE 50 MG TABLET IN BULK AND PHARMACEUTICAL PREPARATIONS
AbstractTiemonium Methylsulfate is an antispasmodic drug. It strengthens calcium bonding with phospholipids and proteins. A simple, sensitive and highly accurate UV spectroscopic method has been developed for the determination of Tiemonium Methylsulfate in bulk and its tablet dosage form. Tiemonium Methylsulfate in its distilled water solutions was determined at the wavelength range of 200-400 nm by the spectroscopic method. Solution of Tiemonium Methylsulfate in distilled water shows a maximum absorbance at 234 nm. Beer’s law was obeyed in the concentration of 10-30µgmL-1, correlation coefficient, detection and quantification limit were also calculated. The proposed method has been applied successfully to assay of Tiemonium Methylsulfate in pure and tablet dosage form. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The percentage of assay of Tiemonium Methylsulfate in tablet was 99.90-100.12% of the label claimed 50 mg per tablet. The method was then validated statistically as per ICH guidelines which yielded good results concerning range, precision, accuracy, reproducibility, specificity and ruggedness.
Article Information
32
548-555
502KB
3298
English
IJPSR
Md. Saiful Islam, Wahiduzzaman, Md. Shafiqul Islam, Md. Rafiquzzaman, Sukalyan Kumar Kundu*
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
skkbd415@yahoo.com
24 September, 2013
25 December, 2013;
12 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).548-55
01 February, 2014
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