VALIDATED UV SPECTROSCOPIC METHOD FOR ESTIMATION OF MONTELUKAST SODIUM
AbstractMontelukast sodium is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies1-2. Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth3. Montelukast is usually taken once a day with or without food3. The present study describes a simple, accurate reproducible and precise uv spectrophotometric method for the estimation of Montelukast Sodium in bulk and in tablet dosage form. The absorbance maxima (λmax) for Montelukast Sodium were found to be 286.5nm. The method was validated for different parameters such as molar absorptivity, accuracy precision, ruggedness, robustness, detection limit, quantification limit etc, (as per ICH guidelines). The relative standard deviation (RSD) in case of, accuracy precision, ruggedness, robustness was less than 2.0% proving that method was highly accurate, precise and robust. This method can be used for determination of Montelukast Sodium in pharmaceutical formulations without interference of the excipients
Article Information
20
4728-32
379
1923
English
IJPSR
Kuldeep Singh*, Paramdeep Bagga, Pragati Shakya, Arun Kumar, M. Khalid, J. Akhtar and M. Arif
Faculty of Pharmacy, Integral University, Kursi road, Lucknow, Uttar Pradesh, India
kuldeepsani2020@gmail.com
10 May, 2015
07 July, 2015
30 September, 2015
10.13040/IJPSR.0975-8232.6(11).4728-31
10.13040/IJPSR.0975-8232.6(11).4728-31
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