WOUND HEALING ACTIVITIES OF FICUS RACEMOSA LEAVES ETHANOLIC EXTRACT ON EXCISION WOUND MODEL OF WISTAR ALBINO RATSAbstract
Present study describes wound healing activities of Ficus racemosa (Linn.) leaves extract on excision wound model of wistar albino rats. During the study, fresh plant materials after shade drying was used for the isolation of extract using soxhlet apparatus and percentage yield was obtained (3.50% in ethanol). Then, preliminary phytochemical screening of the extract was done and certain secondary metabolites viz. alkaloids, glycosides, tannin and flavonoid were confirmed in the Ficus racemosa extract. Then, thin layer and column chromatography of the extract was done and Rf value 0.12 and 0.84 were calculated and obtained fractions (FR-1 to FR-5) were tested on Wistar albino rats for wound healing activities. In the results of the present study, complete wound healing activity was found to be maximum 84.36% on day 17 when treated with mupirocin 5% ointment. Similarly, complete wound healing activity was found 81.30% on day 18th, by applying ethanolic extract of Ficus racemosa as compared to the control group i.e. 62.22% on day 24th.
Rajesh Bakoriya , Tessy Thomas and Kapil K. Soni*
Department of Bioscience, Barkatullah University, Bhopal, Madhya Pradesh, India
02 November, 2014
18 January, 2015
14 May, 2015
01 June, 2015