WOUND HEALING ACTIVITY OF AQUEOUS EXTRACT OF LEPTADENIA RETICULATA IN WISTAR ALBINO RATS
AbstractHerbal medicines have been widely utilized as effective remedies for the prevention and treatment of multiple health conditions for centuries by almost every known culture. Leptadenia reticulata belonging to the family Asclepiadaceae is an important medicinal plant which is used for various ailments. In the present study, an attempt was made to study the wound healing activity of aqueous extract of Leptadenia reticulata (AELR) using excision and burn wound models. In each model, animals were divided into three groups (n=6). Group I served as disease control group, received gel base, group II received AELR gel 10% and group III served as standard and received povidone-iodine 10% ointment. AELR gel 10% showed a significant (P<0.01) in both excision and burn wound models, which was comparable with the standard povidone iodine 10% ointment. Wound healing activity was also confirmed by histopathological studies. The present study suggested that topical application of aqueous extract of Leptadenia reticulata gel 10% plays an important role in wound healing activity. These finding could justify the inclusion of aqueous extract of Leptadenia reticulata in the management of wound healing
Article Information
41
1240-44
546
1258
English
IJPSR
B. Sneha*, M. Ganga Raju and Veeresh Babu
Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, India.
snehabherji@gmail.com
05 September, 2015
19 November, 2015
12 December, 2015
10.13040/IJPSR.0975-8232.7(3).1240-44
01 March, 2016
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