DESIGN, DEVELOPMENT AND EVALUATION OF A NEW POLYHERBAL MOUTH WASH FOR ANTIBACTERIAL POTENCY AGAINST ORAL BACTERIAAbstract
A new Polyherbal Mouth Rinse was formulated comprising of polyherbal extracts of grapes peel, neem, clove, fennel and ginger based on their traditional applications. The extracts used in the formulation and polyherbal mouth rinse both were subjected for anti-bacterial activity separately. Phytochemical tests and spectral studies of the extracts have indicated the presence of polyphenolic compounds- mainly trans-resveratrol and the UV-Vis spectrum also shown the presence of trans-resveratrol at 260 nm. This compound is reported to have wide applications. Both the extracts and polyherbal mouth rinse have shown good sensitivity towards microorganisms like S. aureus, S. mutans and E. fecalis. These study results shows that the presence of compounds like glycosides, terpenoids, flavanoids and saponins which may be responsible for the antibacterial efficacy of the extracts and polyherbal mouth rinse against the these microorganisms which are mostly found responsible for bacterial infections in oral cavity. However further study is needed to confirm this.
T. A. Kalkundri and B. M. Dinnimath *
Department of Pharmachemistry, KAHER’s College of Pharmacy, Hubballi, Karnataka, India.
25 March, 2018
27 June, 2018
02 July, 2018
01 December, 2018