EVALUATION OF ETHANOLIC LEAF EXTRACT OF CEIBA PENTANDRA FOR ANTI-OBESITY AND HYPOLIPIDAEMIC ACTIVITY IN CAFETERIA DIET (CD) TREATED WISTAR ALBINO RATSAbstract
Ceiba pentandra (C. pentandra) has been traditionally used in the ayurveda system of medicine for the treatment of obesity and atherosclerosis. The present study was undertaken to evaluate anti-obesity and hypolipidaemic activity of the ethanolic leaf extract of C. pentandra in Cafeteria diet (CD) treatedWistar albino rats. Obesity was induced in Wistar albino rats by feeding CD daily for twelve weeks. Body weight was measured initially and then every week thereafter. Food and water intake was measured daily. On day 85th, the serum biochemical parameters were estimated and the animals were sacrificed with over dose of anesthetic ether. The liver and fat pads (perirenal, mesenteric and epididymis) were removed and weighed immediately. The intestinal activity of enzyme alkaline phosphatase (ALP) was determined. Administration of C. pentandra (125 mg/kg) prevented the increase in body weight in cafeteria diet treated animals. Administration of C. pentandra showed significant decrease in body weight gain in CD treated obese rats. The significant decrease in ALP level was observed in C. pentandra treated rats. Administration of C. pentandra showed significant decrease in the weight of liver and fat pads as compared to CD control and BMI (g/cm2) was lowered. Results of this study showed that C. pentandra has anti-obesity activity which may partly be mediated via inhibition of intestinal lipid absorption and thermogenesis. In conclusion, the results of this study showed that C. pentandra has therapeutic potential in the management of obesity.
Amol Patil, P. A. Thakurdesai, Shrikant Pawar* and Kedar Soni
Department of Pharmacology, STE’S Smt. Kashibai Navale College of Pharmacy, Pune, Maharashtra, India
24 April, 2012
14 May, 2012
21 July, 2012
01 August, 2012