QUANTITATIVE DETERMINATION OF ETODOLAC BY UV SPECTROPHTOMETRIC METHOD IN BULK DRUG AND COMMERCIAL FORMULATIONSAbstract
The rapid and sensitive UV spectrophotometric method was described for the determination of etodolac, non-steroidal anti-inflammatory drugs. The type of solvent, the range of wavelength and the range of concentration were chosen in order to optimize the conditions. The developed and validated method was successfully applied to the analysis of etodolac without derivatization with any compound in commercial formulations. The standard calibration curve of etodolac was constructed by plotting absorbance versus concentration in the determined concentration range with the final dilution. The calibration curve was Absorbance in 277 nm wavelength = 0.0303 Concentration in ppm –0.0201 and linear (R³0.9995) in concentration range of 1-50 ppm of etodolac. The LOD and LOQ values of method were 0.7 ppm and 1.0 ppm, respectively. Moreover, the proposed method was fast with respect to analysis time as compared to more sophisticated chromatographic techniques.
Pinar Demirci Insuyu, Alptug Atila, Yucel Kadioglu* and Atakan Turan
Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey
20 March, 2013
05 June, 2013
27 July, 2013
01 August, 2013