MOLECULAR DESIGN AND DOCKING STUDY OF NOVEL QUINOXALINE-CONTAINING COMPOUNDS AS PI3K/MTOR DUAL INHIBITOR
AbstractThe PI3K-AKT-mTOR signaling pathway is widely used in cancer therapy as it is a signaling pathway that is frequently disrupted in human cancers. Increasingly, inhibitors develop against key proteins in signaling pathways, such as PI3K and mTOR. Dual inhibitors targeting PI3K and mTOR are more potent than one inhibitor targeting only a single protein. This study used to design and molecular docking analysis to investigate the precise binding positions and interaction forces of quinoxaline-containing compounds within the active site of PI3Kγ and mTOR with the help of freely available software for virtual screening of compounds, docking, and drug interaction result analysis. And also proposed the development of new potent drug candidates which works as dual inhibitors against cancer diseases; thus it could be concluded that Quinoxaline-containing derivatives might be used as a template for destiny improvement thru change or derivatization to lay out stronger healing agents.
Article Information
27
4513-4523
1679 KB
278
English
IJPSR
Sandhya Jain * and Surya Prakash Gupta
Rajiv Gandhi Institute of Pharmacy, Faculty of Pharmaceutical Sciences & Technology, AKS University Satna, Madhya Pradesh, India.
sandhyaj88o@gmail.com
21 January 2023
23 March 2023
25 April 2023
10.13040/IJPSR.0975-8232.14(9).4513-23
01 September 2023
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