EFFECT OF CEFIXIME ON PHARMACOKINETICS OF NEBIVOLOL IN HYPERTENSIVE PATIENTS
AbstractThe present study was carried out to assess the pharmacokinetic drug interaction between nebivolol and cefixime following single oral dose administration in hypertensive patients. Therapeutic dose of nebivolol alone and combination with cefixime were administered to a separate group of hypertensive patients. Serial blood samples were collected at pre-dose (0.0) to 48 h post-dose following each treatment to characterize the pharmacokinetic parameters. The plasma nebivolol concentrations were estimated by a sensitive liquid chromatographic mass spectrometry (LC-MS) method. Mean (SD) of AUC0-t (ng.h/mL) and AUC0–∞ (ng.h/mL) for nebivolol given as a combination versus nebivolol alone is 39.24 (6.96) vs. 17.29 (4.60) and 45.30 (6.70) vs. 24.42 (5.08) respectively. Corresponding values for Cmax (ng/mL) is 2.98 (0.47) vs. 3.09 (0.37). Cefixime significantly increased the extent of exposure of nebivolol when used in combination. There was minor change in the peak exposure and elimination parameters. The results indicate that there observed to be a pharmacokinetic interaction when nebivolol is administered in combination with cefixime. Hence, the combination is contraindicated or used with caution in a clinical situation
Article Information
33
4362-4365
317KB
1195
English
IJPSR
B. Venkateswarlu*, D. Jayaprakash , Ravindernath Anisetti , N. Narsaiah and M. Ravindra Reddy
Administration, KarimNagar, Andhra Pradesh, India
venkatbdi_dca@yahoo.com
23 June, 2013
25 July, 2013
25 October, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4362-65
01 November, 2013
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