EVALUATION OF IN-VITRO ANTIFUNGAL POTENTIALITIES AND GC/MS SPECTROSCOPIC APPROACH OF CLEISTANTHUS COLLINUS (ROXB.) BENTH. EX. HOOK. F.

India is the home to the familiar plant Cleistanthus collinus (Roxb.) Benth. ex Hook. F (Euphorbiaceae) has great ethnomedicinal and therapeutic applications. The present study was designed to assess the phytochemical profile and investigate the antifungal effectiveness of leaf, bark and fruit extracts by using the agar well diffusion method. All crude extracts from leaf, bark, fruit and fractions derived also demonstrated significant antifungal activity (20-80%), but the methanol extracts showed a remarkable antifungal spectrum; as a result, GC-MS analysis was performed on it. From this GC-MS analysis, 14 chemicals, including alkanes, glycosides, phenols, flavonoids and steroids were identified, while leaf methanol extract has high phytochemical diversity with 9 compounds than bark with 6 compounds and fruit with 5 compounds. 1, 2, 3-Benzenetriol, 3-O-Methyl-d-glucose and Undecane are a few significant molecules with larger area percentages that demonstrated biological value. These compounds have been linked to anti-cancer, anti-inflammatory, anti-microbial and antioxidant properties. The current results collectively highlight the appreciable antimicrobial potential of C. collinus and its numerous chemical compounds that are physiologically active and offer a thorough understanding of the phytochemical profile, which could be exploited to create plant-based medications.